The Dow climbed 0.3 percent at New York's open, while the broad-based S&P 500 rose 0.2 percent.

Almost all Asian markets closed higher, with Hong Kong's Hang Seng up 0.1 percent and Shanghai up 0.8 percent.

Main European indices though were slightly lower in late afternoon, amid caution as to what might come out of the meeting of top US and Chinese officials.

London and Frankfurt were trading around 0.6 percent lower, while Paris was nearly one percent down.

"No one truly knows where the US-China trade drama is headed. What's certain is that equity traders have priced in some sort of deal -- however ambiguous," said Fawad Razaqzada, analyst at Forex.com and City Index.

Pakistan's stock market closed down three percent after missile strikes from India, while New Delhi's Sensex reversed early losses to finish up 0.13 percent. The two countries exchanged artillery fire across their contested border.

The dollar rose modestly on news of the US-China talks, and the expectation that the Fed would later Wednesday hold interest rates steady.

The Fed was making its first policy decision since US President Donald Trump unveiled sweeping tariffs on trading partners and ramped up those on China to 145 percent. Beijing has retaliated with 125-percent levies on US imports.

"It seems the market is comfortable enough waiting for the next Fed rate cut in July," and awaiting "hard data" to see how far the central bank might go then, ING Think analyst Chris Turner said.

Among company shares, Disney soared more than 10 percent after it said quarterly sales were up seven percent, partly on picking up 1.4 million subscribers to its Disney+ streaming service -- after analysts had widely expected a decline.

The US entertainment giant also announced plans to open a theme park in the United Arab Emirates.

In Europe, the Danish drugmaker Novo Nordisk, behind the blockbuster weight-loss treatments Ozempic and Wegovy, was trading 1.6 percent up after posting higher quarterly profit and sales.

But the company cut its annual sales forecast, citing a decline in US market share.

Other European pharmaceutical stocks struggled after losses in the United States the previous day.

This followed the appointment of oncologist Vinay Prasad to a top post at the US Food and Drug Administration.

Prasad has been an outspoken critic of the agency's prior approach to Covid-19 vaccines and other key decisions.

In London, drugmaker AstraZeneca saw shares drop nearly two percent, while GSK clawed back some losses but was still some 0.7 percent down. In Paris, Sanofi's shares slid nearly two percent.

German automaker BMW rise 0.9 percent after it said it expected to largely ride out the impact of US tariffs over the coming year.

In a statement, BMW said it expects "some of the tariff increases to be temporary, with reductions from July 2025."

- Key figures at around 1335 GMT -

New York - Dow: UP 0.3 percent at 40.966.78 points

New York - S&P 500: UP 0.2 percent at 5,615.05

New York - Nasdaq: UP 0.1 percent at 17,698.00

London - FTSE 100: DOWN 0.7 percent at 8,540.51

Paris - CAC 40: DOWN 0.9 percent at 7,624.62

Frankfurt - DAX: DOWN 0.6 percent at 23,119.62

Tokyo - Nikkei 225: DOWN 0.1 percent at 36,779.66 (close)

Hong Kong - Hang Seng Index: UP 0.1 percent at 22,691.88 (close)

Shanghai - Composite: UP 0.8 percent at 3,342.67 (close)

Euro/dollar: DOWN at $1.1365 from $1.1373 on Tuesday

Pound/dollar: DOWN at $1.3365 from $1.3370

Dollar/yen: UP at 143.20 yen from 142.44 yen

Euro/pound: UP at 85.06 pence from 85.04 pence

Brent North Sea Crude: DOWN 0.3 percent at $61.99 per barrel

West Texas Intermediate: DOWN 0.3 percent at $58.90 per barrel

burs-rmb/lth

Dow

S&P Global Ratings

GAIN CAPITAL HOLDINGS

ING Groep

The Walt Disney Company

NOVO NORDISK

ASTRAZENECA

GlaxoSmithKline

Sanofi

INDEX CORP.